GG H1 and JETTA

GG H1: Glue Grant H1
A new human transcriptome array for clinical research designed by Stanford University and Affymetrix.

"This array enables comprehensive examination of multiple mechanisms human cells use to regulate transcriptome in response to diseases including improved analysis of gene expression with completely updated gene annotations and carefully redesigned probes, genome-wide quantitation of gene isoforms and identification of alternative splicing, coding and UTR SNP detection and allele specific expression analysis, examination of non-coding transcription and antisense expression, and the analyses of small RNAs.
"

Two significant features:
Software for gene and alternative splicing analysis (JETTA) and visualization
Using exon and junction probes in alternative splicing and isoform analysis
Study of unannotated transcribed units

JETTA is improved and integrative software of some algorithms developed by Wong group for exon array. But it should have more function to deal with non-exon probes, for example junction probes etc. I expect a version of JETTA for Linux in the future.

Anyway, I should admit that GG H1 is a powerful tool to investigate the transcriptome systematically. I just wonder if the hybridization for all of the probes on different regions is uniform. I think the SNPs are detected in DNA level, while splicing and miRNA in the RNA level. How can GG H1 identify all these genotypes in a single array? Anyway,comparing with tilling array, what is the advantage of GG H1? Is it worthy to develop an entirely new product with the existence of exon array and tilling array?

Reference:
http://gluegrant1.stanford.edu/~junhee/JETTA/instructions.html

The reader

Kindle 2, a very cool reader.
It can store 1,500 books; it can go for up to two weeks without a battery recharge; it has a crisper screen.

One must understand simple methods before trying to grasp more complex ones.

One must understand simple methods before trying to grasp more complex ones.

Be even!

Taste the feeling.

在天天向上看到一个非常有意义的东西。

健康产业包括哪些范畴？体检、健身、保健、疾病预防.... 都很有意思，以后注意积累学习。刚才看到一个提肛和辟谷术，一般人看了第一反应是“真TM扯蛋”，另一类觉得“真TM好玩”，第三类在想“会不会是真的啊？”。还有第四类人，就是我，但是我不告诉你们我在想什么。

又顺便扯一下另一个不相干的社会问题，现在的年轻人对中国文化的态度真的太漠然，对社会和政治真的太漠然。“大史纪”里面有一句经典的话：“谁TM给的钱多，我就给谁干”。那些颓废堕落的就不提了，剩下的用全副西方思想和技术武装的一些自我感觉良好的正太们也稍显肤浅。对Microsoft和Google崇拜得跟亲爹妈一样，自以为懂了会用了他们的一些产品，觉得很时尚，很power。真该让老江来好好教育教育：“naive，too naive！”现在中国文化变成了非主流，就像SM一样的地位，尴尬不？

我觉得每个人在思考自己合适做什么时应该内涵外延再广一点，就是这点感想。

码字端一下自己的心态

这两天挺奇妙的，其实很多事情都很顺，但是心绪上却不顺利，BT自己一下。有些事情这样想就误入歧途了。人又不为别人活着，为自己和家庭，如果将来有出息了再为回馈社会。人也不一定要和谁比，人比人气死人直白点讲就是气死自己。再次让我意识到唯心主义的重要性，经过D的错误教育，这个词目前很多时候被认为是贬义词，我要为它拨乱反正。

以前我一直是坚定的唯物主义者，但是我觉得在现今的中国就是太马列唯物主义了，变成了唯物质主义。人之初，性本善，TNND都被生活压力变得虚伪、自保和自私。我不知道是不是大多数人明白了人生的意义。我看到一些不同阶层的人在享受人生的快乐，真的有时不是用金钱来衡量的。但是我也看到一些所谓的高地位、富豪或者著名学者自欺欺人地在生活着。今天的一个会议让我懂了很多人，他们有的真的很善良，有的被社会“熏陶”了，当然了他们都没有错。今天唯一值得高兴一下的是我观察人的能力现在真的很强，我的感情真的很细腻，感觉真的很灵敏，在这方面具有leader的潜质。

我庆幸我快30岁时重新找到了生活的真谛，那是我17，18岁时曾经很接近过，但是被现实所剥离的东西。但是我又发现自己还是不成熟，不禁感叹十年前看过的一部电影里的一句歌词“How many roads must a man walk down?”。How many？

Some bioinformatics ID converters

They are very useful!

http://www.ebi.ac.uk/Tools/picr/
http://david.abcc.ncifcrf.gov/conversion.jsp
http://idconverter.bioinfo.cnio.es/
http://smd.stanford.edu/cgi-bin/source/sourceSearch
http://cbi.labri.fr/outils/alias/

I see the great power of life!

We all left office for a two weeks holiday of the Spring Festival. An ornamental was put close to the central heating and no water. When I was back to office, its leaves are perishing. What it is pity!
I water it immediately and hope it can survive. My feeling is blue for it.
But just two days, it is aglow with health. The power of life is great! We should understand this truth.

A marker for 2009！

A hopeful year for me and my family！

理想和现实的一些思考

作为一种社会型动物，我觉得人们多数需要的是种认同感，尤其是自己所在意的人们认同。所谓理想也多为立志获得这种认同感的目标与抉择，而现实的残酷就可理解为实施目标时对自己预估的偏差或反驳。至于你提到的那四种“理想“或说病态的表现，我看是每个人的阅历迥异让他们的价值观和衡量认同感的标准不同罢了。但是，无论如何，兴趣并不同于理想，但能合二为一无疑最优。实际上我们的兴趣也往往来自于自己的成就，或说自己在某方面的成绩得到了别人或自己的认可，进而有更大的动力主动去做，因此这样看，理想与兴趣也许并不矛盾，关键还是实现理想的过程与历练能否与各人的心理承受所匹配。共勉一下：机会远比安稳重要，事业远比金钱重要，未来远比今天重要。”

以上引用自：http://hustkiwi.javaeye.com/blog/224814

我自居太史公说两句：
理想啊，其实没那么神圣，就是做自己喜欢的事情，这件事呢对大家还有点儿用，就可以了。千万别为了理想而理想，别为了虚荣而理想。